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Indirect evidence for oxidative stress in ADHD comes from studies showing some treatment efficacy for antioxidant compounds such as omega-3 fatty acids, pycnogenol, and N -acetylcysteine (NAC)

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Drug resistance mechanisms beyond DPP9-NRF2 (255) and AIM2-FOXO3a (258) are also underexploredwhether epigenetic modifications (e.g., DNA methylation of ACSL4), post-translational regulation (e.g., GPX4 ubiquitination), or metabolic rewiring (e.g., alternative antioxidant pathways) drives acquired resistance to ferroptosis inducers requires investigation